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Joseph G. Lorenz Print E-mail
ImageJoseph G. Lorenz, Ph.D. is a molecular anthropologist in the Molecular Biology Group at the Coriell Institute for Medical Research. Dr. Lorenz is interested in the geographic and ethnic distribution of genetic variation among human populations, both modern and ancient. Understanding the pattern of genetic variation is a necessary first step to unraveling the interaction of genes and environments that produce the variety of phenotypes characteristic of our species. These phenotypes include the susceptibility and resistance to many of the diseases that afflict us. In addition, Dr. Lorenz is interested in the comparative genetics of the Order Primates. A true understanding of the nature of human genetic variation can only be gained by looking at our species within an evolutionary framework.

Dr. Lorenz oversees the operation of the Integrated Primate Biomaterials and Information Resource, an NSF funded resource for cell lines and DNA from over forty species of nonhuman primates representing the major taxonomic groups of the Order Primates. He also oversees the operation of the collection of cell lines and DNA representing the chimpanzees from the Yerkes National Primate Research Center.

Dr. Lorenz received his Ph.D. from the University of California at Davis in 1995 where he studied mitochondrial DNA variation among American Indians. He then spent two years in a forensic/paternity testing laboratory in Denver, Colorado. In the fall of 1997, Dr. Lorenz began a postdoctoral research fellowship at the National Institute of Alcohol Abuse and Alcoholism at the National Institutes of Health in Rockville, Maryland where he studied the quantitative genetics of alcohol consumption in rhesus macaques and began to identify candidate loci that could be screened for polymorphisms.


Representative Publications

Kemp, BM, Malhi, RS, McDonough, J, Bolnick, DA, Eshleman, JA, Rickards, O, Martinez-Labarga, C, Johnson, JR, Lorenz, JG, Dixon, EJ, Fifield, TE, Heaton, TH, Worl, R, Smith, DG. Genetic analysis of early Holocene skeletal remains from Alaska and its implications for the settlement of the Americas. American Journal of Physical Anthropology.132(4)::605-21, 2007.
PMID:17243155 abstract

Scheinfeldt, L, Friedlaender, F, Friedlaender, J, Latham, K, Koki, G, Karafet, T, Hammer, M, Lorenz, J. Y Chromosome Variation in Island Melanesia. IN: Population Genetics, Linguistics, and Culture History in the Southwest Pacific: A Synthesis (Jonathan S. Friedlaender, ed.) Oxford University Press, 2007.

Scheinfeldt, L, Friedlaender, F, Friedlaender, J, Latham, K, Koki, G, Karafet, T, Hammer, M, Lorenz, J. Unexpected NRY chromosome variation in Northern Island Melanesia. Molecular Biology and Evolution23(8)::1628-41, 2006.
PMID:16754639 abstract

Johnson, JR and Lorenz, JG. Genetics, Linguistics, and Prehistoric Migrations: An Analysis of California Indian mtDNA Lineages. Journal of California and Great Basin Anthropology 26(1):33-64, 2006.

Lorenz, JG, Long, JC, Linnoila, M, Goldman, D, Suomi, SJ, Higley, JD. Genetic and other contributions to alcohol intake in rhesus macaques (Macaca mulatta). Alcoholism: Clinical and Experimental Research. 30(3):389-98, 2006.
PMID: 16499479 abstract

Lorenz, JG, Jackson, WE, BeckJC, Hanner, R. The problems and promise of DNA barcodes for species diagnosis of primate biomaterials.Philosophical Transactions of the Royal Society of London. B. 360(1462):1869-1877, 2005.
PMID: 16214744 abstract

Eshleman, JA, Malhi, RS, Johnson, JR, Kaestle, FA, Lorenz, J, Smith, DG. Mitochondrial DNA and prehistoric settlements: native migrations on the western edge of North America. Human Biology 76(1):55-75, 2004.
PMID: 15222680 abstract

Malhi, RS, Mortensen, HM, Eshelman, JA, Kemp, BM, Lorenz, JG, Kaestle, FA, Johnson, JR, Gorodezky, C, Smith, DG. Native American mtDNA prehistory in the American Southwest. American Journal of Physical Anthropology 120(2):108-124, 2003.
PMID: 12541329 abstract

Malhi, RS, Eshelman, JA, Greenberg, JA, Weiss, DA, Schultz Shook, BA, Kaestle, FA, Loenz, JG, Kemp, BM, Johnson, JR, Smith, DG.
The structure if diversity within New World mitochondrial DNA haplogroups: implications for the prehistory of North America. American Journal of Human Genetics 70(4):905-919, 2002.
PMID: 11845406 abstract  full text

Bennett AJ, Lesch KP, Heils A, Long JC, Lorenz JG, Shoaf SE, Champoux M, Suomi SJ, Linnoila MV, Higley JD.
Early experience and serotonin transporter gene variation interact to influence primate CNS function. Molecular Psychiatry 7(1):118-122, 2002.
PMID: 11803458 abstract

Rolfs, BK, Lorenz, JG, Wu, CC, Lerche, NW, and Smith, DG.
Mamu-DQA1 allele and genotype frequencies in a randomly sampled breeding colony of rhesus macaques. Comparative Medicine 51(2):156-162, 2001.
PMID: 11922180 abstract

Smith, DG, Lorenz, JG, Rolfs, BK, Bettinger, RL, Green, B, Eshleman, J, Schultz, B, Malhi, R.
Implications of the Distribution of Albumin Naskapi and Albumin Mexico for New World Prehistory. American Journal of Physical Anthropology 111:557-572, 2000.
PMID: 10727973 abstract

Fahlke, C, Lorenz, JG, Long, J, Champoux, M, Suomi, SJ, Higley, JD.
Rearing Experiences and Stress-induced Plasma Cortisol as Early Risk Factors for Excessive Alcohol Consumption in Nonhuman Primates. Alcoholism: Clinical and Experimental Research 24(5):644-650, 2000.
PMID: 10832905 abstract

Long, JC and Lorenz, JG.
Genetic Polymorphism and American Indian Origins, Affinities, and Health. In: The Health of American Indians and Alaska Natives (Ed. Rhoades, ER), Baltimore: Johns Hopkins University Press, pp. 122-137, 2000.

Kaestle, FA, Lorenz, JG, Smith, DG.
Molecular Genetics and the Numic Expansion: A Molecular Investigation of the Prehistoric Inhabitants of Stillwater Marsh. In: Prehistoric Lifeways in the Great Basin Wetlands (Eds. Hemphill, B and Larsen, CS), Salt Lake City: University of Utah Press, 1999.

Smith, DG, Malhi, RS, Eshleman, J, Lorenz, JG, Kaestle, FA.
Distribution of mtDNA Haplogroup X among Native North Americans. American Journal of Physical Anthropology 110(3):271-284, 1999.
PMID: 10516561 abstract

Lorenz, JG and Smith, DG.
Distribution of Sequence Variation in the mtDNA Control Region of Native North Americans. Human Biology 69(6):749-775, 1997.
PMID: 9353972 abstract

Lorenz, JG and Smith, DG.
Distribution of Four Founding mtDNA Haplogroups Among Native North Americans. American Journal of Physical Anthropology 101(3):307-323, 1996.
PMID: 8922178 abstract

Bouey, P, Lorenz, JG, Spero, H.
Stable Isotopes. In: Report of the Archaeological Analysis of CA-SAC-43, Cultural Resource Mitigation for the Sacramento Urban Area Levee Reconstruction Project. Submitted to the U. S. Army Corp of Engineers, Sacramento District, Sacramento Cty., CA, 1995.

Lorenz, JG and Smith, DG.
Distribution of the 9-bp Mitochondrial DNA Region V Deletion among North American Indians. Human Biology 66(5): 777-788, 1994.
PMID: 8001909 abstract

 
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